| Application | 4-methoxybenzo [D] oxazol-2 (3H)-Thione can be used as a pharmaceutical intermediate to synthesize other compounds with certain activity, and its application is rarely reported. Analogs of 4-methoxybenzo [D] oxazol-2 (3H)-thione [5-methoxybenzo [d] oxazol-2 (3h)]-Thione] is a key intermediate impurity of omeprazole, a first generation benzimidazole gastric acid proton pump inhibitor developed by Astra Zen-eca company in Sweden, mainly used for the treatment of peptic gastric ulcer and reflux gastritis. According to the European Pharmacopoeia EP8.0, Omeprazole has 9 known impurities (A ~ I,Chart 1): impurity A is the key intermediate of omeprazole, 5-methoxy-1h-benzo [d] imidazole-2-thiol, and impurity B- I is the process impurity and degradation impurity of Omeprazole. |
![4-methoxybenzo[d]oxazole-2-thiol](http://res.chembk.com/assets/str/2d/1/12/1246471-39-5.png)